Pregnancy and Endometriosis

Pregnancy is something that many women with endometriosis may have thought about or experienced, because endometriosis often first affects women when they are of childbearing age. There is evidence that having endometriosis may affect your fertility and suggests that endometriosis can lead to complications during pregnancy.1–4 However, being pregnant can improve the symptoms of endometriosis5 and is often a time of celebration and joy, in addition to the usual maternal concern for the health of your baby.

How do I participate?

Fill out the contact form to have a registry representative contact you with more information about this pregnancy registry

Call the registry's toll-free number
1-(833)-782-7241 and speak to a registry representative

Ask your healthcare provider to help you complete the contact form

Does pregnancy make endometriosis worse?

In many women, pregnancy does not make the symptoms of endometriosis worse.

In fact, some women find that their endometriosis symptoms improve during pregnancy.5 However, this improvement is often temporary, and the symptoms of endometriosis will likely come back after pregnancy or breastfeeding.5

In some cases, pain can worsen due to the extra pressure of the uterus on nerves or areas with existing endometrial tissue.6

If I have a baby girl, is she at risk of getting endometriosis?

There does not appear to be a clear reason why women develop endometriosis, but genetics are thought to play a role. Women with a first-degree relative with endometriosis do appear to be at greater risk of developing the condition.7 Your daughter may develop the disease as she matures, but hopefully by that time research will have led to a greater understanding of endometriosis.

How will endometriosis treatment affect my baby?

All pregnant women are advised to think carefully about any substances (e.g. foods, drinks, and medications) they put into their body. This is because some substances can move from the mother’s bloodstream directly to the baby’s bloodstream (through the placenta). It is unlikely that you will be receiving any treatment for endometriosis during your pregnancy, but this would be a decision between you and your doctor.

In many cases, when a woman receives a medication, the effect of that medication on the health of her baby is often not known. This is because pregnant women are often prohibited from participating in studies that test potential new medications. However, pregnancy registries are studies designed to potentially help healthcare providers learn more about medications and their effects on babies. The aim is to gather information that will help women and their healthcare providers make informed decisions in the future about their medication use before or during pregnancy.

In some cases, women do not yet know that they are pregnant when taking medication. Sharing your pregnancy information with this registry could help provide information as to whether taking Orilissa® (elagolix) early in pregnancy could have an effect on the pregnancy or the health of the baby. It is not known at this time if Orilissa could harm your unborn baby. Orilissa is not approved for use in pregnancy, and women are advised to stop taking it immediately if they become pregnant.

Learn about the BLOOM Pregnancy Registry here.

Where can I go for help and advice?

Your own healthcare provider should be the first source of information for you about your pregnancy and endometriosis. In addition, there are endometriosis patient advocacy groups where you can seek information from people who may have experience with endometriosis and pregnancy. Your healthcare provider may be able to help you contact a group that is active in your local area.

For the latest important safety information, please refer to the full Prescribing Information and Medication Guide. This is not intended to replace discussions with your healthcare provider.


  1. Saraswat L, Ayansina DT, Cooper KG, et al. Pregnancy outcomes in women with endometriosis: a national record linkage study. BJOG. 2017;124:444–452. Available at Accessed 3 August 2020.
  2. Kronemyer B. Adverse effects of endometriosis on pregnancy. Contemp Ob Gyn. 2019;Dec 4. Available at Accessed 3 August 2020.
  3. Schwartz B. Does endometriosis lead to increased risk of adverse pregnancy outcomes. Contemp Ob Gyn. 2019;Aug 22. Available at Accessed 3 August 2020.
  4. Prescott J, Farland LV, Tobias DK, et al. A prospective cohort study of endometriosis and subsequent risk of infertility. Hum Reprod. 2016;31:1475‒1482. Available at Accessed 3 August 2020.
  5. Medical News Today. What to know about endometriosis during pregnancy. Accessed 3 August 2020.
  6. Leeners B, Damaso F, Ochsenbein-Kölble N, et al. The effect of pregnancy on endometriosis-facts or fiction? Hum Reprod. 2018;24:290‒299. Available at Accessed 3 August 2020.
  7. Hansen K, Eyster K. Genetics and genomics of endometriosis. Clin Obstet Gynecol. 2010;53:403–412. Available at Accessed 3 August 2020.

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